γ-Radiolyses of DNA in Oxygenated Aqueous Solution. Structure of an Alkali-Labile Site

Abstract

Erythritol-l-d1 was isolated from .gamma.-irradiated aqueous oxygenated solution of DNA after reduction with NaBD4, alkali and phosphate treatment. This product apparently stems from a D-erythrose 2,4-diphosphate unit in the DNA which is formed via a sequence of reactions following H-abstraction at C-2'' by OH radicals.