Mechanism of the resistance to cytotoxicity which precedes aflatoxin B1 hepatocarcinogenesis
- 1 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 2 (5), 457-461
- https://doi.org/10.1093/carcin/2.5.457
Abstract
In vivo there is evidence for a decreased covalent binding of aflatoxin B 1 to DNA following low-level feeding with the toxin. It is suggested that this is due to increased detoxification of aflatoxin B 1 by conjugation with reduced glutathione. Evidence indicating increased levels of reduced glutathione and glutathione S-trans-ferase activity are presented.This publication has 13 references indexed in Scilit:
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