Comparison of helium dilution and nitrogen washout measurements of functional residual capacity in infants and very young children

Abstract

In infants and very young children, functional residual capacity (FRC) is the lung volume most frequently measured and gas dilution techniques are most frequently used to measure FRC. We compared measurements of FRC by helium dilution (FRC_He) and nitrogen washout (FRC) in a lung model of known volumes (20,40,60,80 mL), in 8 normal infants (NL), 8 infants with acute respiratory illness (ARI), and 7 infants with chronic lung disease (CLD). In the model lung, measurements of FRC_He had a significantly greater coefficient of variation compared to FRC (6.5 vs 1.5%, P < 0.02), but there was no such difference in the results from all infants combined (6.5 vs 6.2%). In the model lung, the difference between known volumes and the measured values was significantly different from zero only for FRC_He at 20 mL (−4.4 mL, P 0.02). For both FRC_He and FRC, the slopes of the regression equations were 0.99 and the intercepts not significantly different from zero. We conclude that techniques for measuring FRC_He and FRC yield accurate, reproducible, and comparable results in normal, healthy infants and very young children, and in those with respiratory disease.