Amino acid sequence homology between cholera toxin and Escherichia coli heat-labile toxin

Abstract
The amino acid sequences of LT-B [E. coli heat-labile toxin subunit B] and CT-B] [cholera toxin subunit B] were compared. The nucleotide sequence of the LT-B cistron (eltB) was determined using a recombinant plasmid encoding LT. Translation of this sequence revealed that LT-B and CT-B show significant amino acid sequence homology. Several features of the eltB cistron were revealed by the sequence analysis.