The Synthesis of Glycocyamine in Rat Kidney and a Mechanism of Creatine Synthesis in Vivo

Abstract
Slices of rat kidney form glycocyamine rapidly from arginine and glycine. The reaction is catalyzed by thoroughly macerated kidney tissue at pH 7.4, but not by rat liver slices. Since (as was found previously) glycocyamine is not methylated in the kidney but in the liver, both organs must participate in the formation of creatine.