Genetic control of vaccine‐induced immunity against a parasitic helminth, Schistosoma mansoni
- 1 November 1988
- Vol. 9 (5), 163-166
- https://doi.org/10.1002/bies.950090506
Abstract
Schistosoma mansoni is one of several species of trematode helminths responsible for schistosomiasis, a major parasitic infection of man. Genetic analysis in mice has revealed that the protective immunity induced against this parasite by an attenuated larval vaccine is strongly influenced by genes regulating the activation of macrophage effector cells. The latter finding suggests that the induction of cell‐mediated immunity may be a successful strategy for a non‐living vaccine against the human infection.This publication has 22 references indexed in Scilit:
- Induction of protective immunity against Schistosoma mansoni by a non‐living vaccine. VI. Antigen recognition by non‐responder mouse strainsParasite Immunology, 1988
- Schistosoma spp.: Progress toward a defined vaccineExperimental Parasitology, 1987
- Immunochemical characterization and purification of Sm-97, a Schistosoma mansoni antigen monospecifically recognized by antibodies from mice protectively immunized with a nonliving vaccine.The Journal of Immunology, 1986
- Identification of Paramyosin as Schistosome Antigen Recognized by Intradermally Vaccinated MiceScience, 1986
- Defective vaccine-induced immunity to Schistosoma mansoni in P strain mice. I. Analysis of antibody responses.The Journal of Immunology, 1984
- Mechanisms of protective immunity against 5. mansoni infection in mice vaccinated with irradiated cercariae. VI. Influence of the major histocompatibility complexParasite Immunology, 1984
- Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae III. Identification of a mouse strain, P/N, that fails to respond to vaccinationParasite Immunology, 1983
- Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. IV. Analysis of the role of IgE antibodies and mast cells.The Journal of Immunology, 1983
- Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. II. Analysis of immunity in hosts deficient in T lymphocytes, B lymphocytes, or complement.The Journal of Immunology, 1982
- Defective tumoricidal capacity of macrophages from P/J mice: tumoricidal defect involves abnormalities in lymphokine-derived activation stimuli and in mononuclear phagocyte responsiveness.The Journal of Immunology, 1980