Recognition sequence of bacteriophage ΦX174 gene A protein — an initiator of DNA replication
- 1 December 1980
- journal article
- Published by Springer Nature in Nature
- Vol. 288 (5791), 561-566
- https://doi.org/10.1038/288561a0
Abstract
Gene A protein, the initiator protein of bacteriophage phi X174 DNA replication, cleaves synthetic single-stranded oligodeoxyribonucleotides at the same site as the corresponding sequence at the phi X origin. The results identify the recognition sequence within the decamer CAACTTGATA which is cleaved next to the G residue. Further requirements for cleavage of double-stranded DNA by the gene A protein are supercoiling and an A + T-rich domain adjacent to the recognition sequence.Keywords
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