Active Human Herpesvirus 6 Infection in Patients With Multiple Sclerosis
Open Access
- 1 June 2002
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 59 (6), 929-933
- https://doi.org/10.1001/archneur.59.6.929
Abstract
MULTIPLE SCLEROSIS (MS) is characterized clinically by a variable course and pathologically by a progressive accumulation of demyelinating plaques in the central nervous system white matter. Numerous epidemiologic studies support the hypothesis that MS appears in a genetically predisposed population that may also be affected by an environmental factor, which is probably infectious.1,2 During the last few decades, numerous viruses have been studied, but so far, none have been definitely associated with MS.Keywords
This publication has 25 references indexed in Scilit:
- Tissue Distribution and Variant Characterization of Human Herpesvirus (HHV)–6: Increased Prevalence of HHV‐6A in Patients with Multiple SclerosisThe Journal of Infectious Diseases, 2000
- Human Herpesvirus 6 and Multiple Sclerosis: Systemic Active Infections in Patients with Early DiseaseClinical Infectious Diseases, 2000
- Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patientsJournal of Clinical Virology, 2000
- Detection of Human Herpesvirus 6 Variant A in Peripheral Blood Mononuclear Cells from Multiple Sclerosis PatientsEuropean Neurology, 2000
- Human herpesvirus 6 is latent in peripheral blood of patients with relapsing-remitting multiple sclerosisJournal of Neurology, Neurosurgery & Psychiatry, 1999
- Polymerase chain reaction analysis of human herpesvirus-6 sequences in the sera and cerebrospinal fluid of patients with multiple sclerosisJournal of NeuroVirology, 1999
- Association of human herpes virus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNANature Medicine, 1997
- Plaque-associated expression of human herpesvirus 6 in multiple sclerosis.Proceedings of the National Academy of Sciences, 1995
- Human herpesvirus 6 and multiple sclerosis: survey of anti-HHV-6 antibodies by immunofluorescence analysis and of viral sequences by polymerase chain reaction.Journal of Neurology, Neurosurgery & Psychiatry, 1993
- Three cases of human herpesvirus‐6 latent infection: Integration of viral genome in peripheral blood mononuclear cell DNAJournal of Medical Virology, 1993