The existence of a probable endocrine dysfunction in acne has been assumed for many years. The exact nature of this dysfunction and the identification of the specific factor responsible is still a matter of research and experimentation. Clinical trial of the gonadotropic factor from pregnancy urine has given variable results according to several recent reports. In none of these series were controls run to compare the improvement in patients not receiving the gonadotropic preparation. To determine the effectiveness of gonadotropic substance from pregnancy urine (antuitrin-S) in the treatment of acne, thirty-nine students were studied. These all received the same local treatment but half were given gonadotropic substance and the half used as a control received injections of sterile water. Lawrence1reported favorably on the use of gonadotropic substance from pregnancy urine in a study of two series of acne patients. In his opinion the gonadotropic mechanism was probably the