Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
Open Access
- 22 August 2013
- journal article
- review article
- Published by Hindawi Limited in Mediators of Inflammation
- Vol. 2013, 1-13
- https://doi.org/10.1155/2013/181324
Abstract
Electronegative low density lipoprotein (LDL()) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms. LDL() has inflammatory properties similar to those of oxidized LDL (oxLDL), such as inflammatory cytokine release in leukocytes and endothelial cells. However, in contrast with oxLDL, LDL() also has some anti-inflammatory effects on cultured cells. The inflammatory and anti-inflammatory properties ascribed to LDL() suggest that it could have a dual biological effect.Keywords
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