Simultaneous Identification of Amphetamine and Methamphetamine Using Solid-Phase Extraction and Gas Chromatography/Nitrogen Phosphorous Detection or Gas Chromatography/Mass Spectrometry
- 1 September 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 13 (5), 293-295
- https://doi.org/10.1093/jat/13.5.293
Abstract
A method for the simultaneous detection and quantitation of amphetamine and methamphetamine in urine is described. Using solid-phase extraction, amphetamine, methamphetamine, and n-propylamphetamine (internal standard) are extracted from urine samples. Drugs in their free form are identified using gas chromatography/nitrogen-phosphorous detection (GC/NPD), whereas their heptafluorobutyric anhydride derivatives are detected by gas chromatography/mass spectrometry (GC/MS) in the selected ion monitoring (SIM) mode. Limits of detection for both amphetamine and methamphetamine are approximately 35 ng/mL. The procedure is simple, rapid, and suitable for a large number of specimens (25 or more).This publication has 3 references indexed in Scilit:
- Quantitation of Methamphetamine and Amphetamine in Urine by Capillary GC/MS. Part I. Advantages of Trichloroacetyl Derivatization*Journal of Analytical Toxicology, 1989
- Simultaneous Determination of Methamphetamine and Its Metabolites in Monkey Urine by Gas Chromatography/Mass Spectrometry with Selected Ion MonitoringJournal of Analytical Toxicology, 1989
- Resolution of Methamphetamine Stereoisomers in Urine Drug Testing: Urinary Excretion of R(−)-Methamphetamine Following Use of Nasal InhalersJournal of Analytical Toxicology, 1988