The de novo design and synthesis of cyclic urea inhibitors of factor Xa: Initial sar studies
- 6 October 1998
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 8 (19), 2705-2710
- https://doi.org/10.1016/s0960-894x(98)00471-5
Abstract
No abstract availableKeywords
This publication has 19 references indexed in Scilit:
- Identification and Initial Structure−Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor XaJournal of Medicinal Chemistry, 1998
- Rational Design and Synthesis of Novel, Potent Bis-phenylamidine Carboxylate Factor Xa InhibitorsJournal of Medicinal Chemistry, 1998
- Bisbenzamidine isoxazoline derivatives as factor Xa inhibitorsBioorganic & Medicinal Chemistry Letters, 1997
- Coumadin aspirin reinfarction study: Rationale and design of the CARS studyJournal of Thrombosis and Thrombolysis, 1996
- A molecular mechanics/grid method for evaluation of ligand–receptor interactionsJournal of Computational Chemistry, 1995
- Dibasic (Amidinoaryl)propanoic Acid Derivatives as Novel Blood Coagulation Factor Xa InhibitorsJournal of Medicinal Chemistry, 1994
- Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease InhibitorsScience, 1994
- Structure of Human Des(1-45) Factor Xa at 2·2 Å ResolutionJournal of Molecular Biology, 1993
- The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human α‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationshipsProtein Science, 1992
- Amino‐aromatic interactions in proteinsFEBS Letters, 1986