Fragile Sites in Chromosomes: Possible Model for the Study of Spontaneous Chromosome Breakage
- 1 April 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 220 (4592), 69-70
- https://doi.org/10.1126/science.6828880
Abstract
The tissue culture condition that is required for the type of chromosome breakage seen at most fragile sites, namely, the absence of folic acid and thymidine in the medium, greatly enhanced micronucleus formation in proliferating lymphocyte cultures from normal individuals. This suggests that chromosome breakage at fragile sites and the apparently spontaneous damage that gives rise to micronuclei are controlled by the same mechanism.This publication has 5 references indexed in Scilit:
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- Significance of phenotypic and chromosomal abnormalities in X‐linked mental retardation (Martin‐Bell or Renpenning syndrome)American Journal of Medical Genetics, 1980
- X‐linked mental retardation with macro‐orchidism and marker‐X chromosomesAmerican Journal of Medical Genetics, 1980
- Effect of lead acetate of human leukocyte chromosomes in vitroCellular and Molecular Life Sciences, 1974