Streptocin, Antibiotic Isolated from Mycelium of Streptomyces griseus, Active Against Trichomonas vaginalis, and Certain Bacteria.

Abstract

Several antibiotic substances were found in the ether-soluble extract of the mycelium of various cultures of S. griseus, which differed in their chemical nature and antimicrobial activities. One of these fractions from S. griseus No. 3533, designated as streptocin, possesses strong trichomonicidal properties,particularly against T. vaginalis. It is also active against various Gram-positive bacteria. The crystalline material is soluble in water, methanol, and ethanol but not in CHCl3. It is stable in a pH range of 2-11 and to heat at 100[degree]C for at least 1 hr. Max. production is obtained in static cultures in 5 days. Small amts. of streptocin are also present in the culture filtrate of the organism. Streptocin is distinct from actidione in its physical and chemical properties and in the nature of its antimicrobial spectrum.