A case of whealing response to cold is described. The immunological status was negative. The main feature of the case was the suddenness of onset which immediately followed a relatively short period of mental conflict which endangered the patient' life. Evidence against the histamine theory of “cold allergy” is presented. It is suggested that more accurate data be obtained regarding the nature of the emotional circumstances of the onset of the group of vasomotor responses ordinarily classified as the physical allergies. I am grateful to Dr. Frank Fremont-Smith for critical suggestions in developing the psychosomatic aspects of this report.