MAC for Halothane, Enflurane, and Isoflurane in the New Zealand White Rabbit

Abstract

MAC [minimum alveolar concentration] determinations for halothane, enflurane and isoflurane were performed in New Zealand white rabbits (n = 8, approximate age 6 mo.). The MAC values (.+-. SD) were as follows: halothane 1.39 .+-. 0.23%, enflurane 2.86 .+-. 0.18% and isoflurane 2.05 .+-. 0.18%. Comparison of these results with published MAC values for other species suggests that the ratio of the potencies for any pairing of these 2 agents is constant from species to species. This observation provides a means for assessing the validity of preexisting or newly determined MAC values.