Nonsteroidal antiinflammatory agents. 2. [(Heteroarylamino)phenyl]alkanoic acids
- 1 February 1983
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 26 (2), 222-226
- https://doi.org/10.1021/jm00356a019
Abstract
A series of [(heteroarylamino)phenyl]alkanoic acids having pyridine, quinoline or pyrimidine as the heteroaryl moiety was prepared as potential antiinflammatory agents. Among them, 2-[4-(2-pyridylamino)phenyl]propionic acid (14b) showed excellent antiinflammatory and analgesic activities with less tendency to cause gastric side effects [the studies employed rats and mice]. Structure-activity relationships are discussed.This publication has 6 references indexed in Scilit:
- Nonsteroidal antiinflammatory agents. 1. 10,11-Dihydro-11-oxodibenz[b,f]oxepinacetic acids and related compoundsJournal of Medicinal Chemistry, 1982
- ACCELERATED GRANULOMA-FORMATION IN ADJUVANT-INDUCED ARTHRITIC RATS AND ITS MODIFICATION BY ANTI-RHEUMATIC DRUGS1979
- PHARMACOLOGIC EVALUATION OF TOLECTIN (TOLMETIN, MCN-2559) AND MCN-2891, 2 ANTIINFLAMMATORY AGENTS1973
- Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory DrugsExperimental Biology and Medicine, 1962
- A Method for Evaluating both Non-Narcotic and Narcotic AnalgesicsExperimental Biology and Medicine, 1957
- A SIMPLIFIED METHOD OF EVALUATING DOSE-EFFECT EXPERIMENTS1949