THE INTRAGASTRIC PRESSURE WHICH ABOLISHES THE SECRETION OF ACID

Abstract

An intragastric pressure of from 25 to 30 mm. Hg abolishes the secretion of HC1 in response to hista-mine in anesthetized dogs. It is suggested that this may be due to a disturbance of the acid-producing mechanism in the parietal cell secondary to a decrease in venous outflow. Neutral red is still excreted by the cells lining the gastric tubule when the pressure is high enough to prevent acid from being formed. The values usually assigned for the "secretory pressure" of bile and pancreatic juice may not represent a true measure of the secretory pressure of the hepatic and pancreatic cells.