Analysis of Norethindrone In Plasma by High-Performance Liquid Chromatography
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 4 (5), 871-877
- https://doi.org/10.1080/01483918108059981
Abstract
A sensitive specific high-performance liquid chromatographic procedure for the determination of norethindrone in plasma is described. The organic solvent extract from plasma is chromatographed on a reversed phase column using a high-performance liquid chromatograph fitted with an ultraviolet detector (254 nm); quantitation from plasma samples containing 2 ng/ml norethindrone is reported. Metabolites and endogenous substances do not interfere with the assay. The determination of norethindrone concentrations in plasma following administration of single oral dose to a mini-pig is described.Keywords
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