Renin‐like activity of the rat submaxillary gland: characterization and the effect of several drugs and stimuli

Abstract

1 Renin-like activity was found in rat submaxillary glands. 2 This activity was destroyed by boiling, was non-dialyzable and showed an optimum at approximately 50° C. 3 Renin-like activity in the submaxillary gland was not diminished 24 h after nephrectomy but was considerably reduced after ligature of the submaxillary duct. 4 Renin-like activity in the submaxillary gland was reduced following food-deprivation, water-deprivation or hypovolemia. 5 Renin-like activity in the rat submaxillary gland was increased after isoproterenol administration but not following pilocarpine. 6 Renin-like activity in the rat submaxillary gland was increased considerably by administration of NaCl or KCl, as well as following adrenalectomy. 7 Chlorothiazide and ouabain increased submaxillary renin-like activity but diazoxide did not affect this activity.