Brush Border Antibodies of Heymann Nephritis of Rats in Normal Human Serum

Abstract

Brush border antibody of Hey-mann nephritis of rats was detected in 36.0% of normal human sera by indirect immunofluorescence technique. Persons with blood group B were less likely to develop this antibody. Its existence in the serum may or may not be related to the genesis of idiopathic membranous glomerulo-nephropathy in humans. Many investigators are looking for BB Ab in the sera of patients with renal disease; thus, it is important to know that BBAb can exist in the sera of normal human controls who do not have any clinical evidence of renal disease. Further studies on this subject will be needed to understand the significance of this observation. Possibilities to explain this observation are presented.