Colonic absorption of unconjugated bile acids
- 1 July 1979
- journal article
- research article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 24 (7), 545-550
- https://doi.org/10.1007/bf01489324
Abstract
Colonic absorption of three major unconjugated bile acids—cholate, chenodeoxycholate, and deoxycholate—was measured under steady-state conditions using a technique of colonic perfusion in healthy volunteers. Aqueous solutions at pH 8.0 and varying in concentration from 1 mM to 10 mM were used. The rate of chenodeoxycholate absorption averaged nine times that of cholate absorption; deoxycholate absorption was somewhat less than that of chenodeoxycholate absorption, averaging six times that of cholate. At concentrations below 5 mM, the rate of absorption of bile acids was directly proportional to concentration, so that “clearance” could be calculated. Clearance values for a 1-mM solution (ml/min/colon, mean ±se) were: chenodeoxycholate, 9.84±1.0; deoxycholate, 7.0±1; and cholate, 0.82±0.10. Since absorption was proportional to concentration in the lumen, and was more rapid for the dihydroxy acids, the major mechanism of absorption was thought to be passive nonionic diffusion. Maximal rates of bile acid absorption were calculated from a 1-mM solution and found to be as high as 4.2 g/day for chenodeoxycholate, 3.2 g/day for deoxycholate, and 0.5 g/day for cholate, and the rate would be still greater for more concentrated solutions. Colonic absorption may contribute significantly to conservation of the dihydroxy bile acid pool, especially in conditions of bile acid malabsorption.This publication has 51 references indexed in Scilit:
- Rabbit ileal mucosa exposed to fatty acids, bile acids, and other secretagoguesDigestive Diseases and Sciences, 1977
- Fecal bile acids and neutral sterols in patients with familial polyposisCancer, 1976
- The intermicellar bile salt concentration in equilibrium with the mixed-micelles of human bileBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1975
- Factors Affecting Bile Acid Metabolism in Cholerrheic EnteropathyDigestion, 1974
- Effect of Glycine-Conjugated Bile Acids with and without Lecithin on Water and Glucose Absorption in Perfused Human JejunumJCI Insight, 1973
- Faecal Bile Acids and Neutral Steroids in Patients with Ileal DysfunctionScandinavian Journal of Gastroenterology, 1972
- Effects of sodium concentration and osmolality on water and electrolyte absorption from the intact human colonJCI Insight, 1969
- An improved method for measuring human blood bile acidsClinica Chimica Acta; International Journal of Clinical Chemistry, 1968
- Studies on the adsorption of bile salts to non-absorbed components of dietBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1968
- Faecal excretion products of cholic acid in manBritish Journal of Nutrition, 1964