Sequential Carcinoembryonic Antigen Levels
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 38 (1), 27-30
- https://doi.org/10.1159/000225516
Abstract
Serial determinations of plasma carcinoembryonic antigen (CEA) levels were assayed for 34 patients with advanced gastrointestinal cancer undergoing 5-fluorouracil and mitomycin C combination chemotherapy. 21 patients (62%) had an objective response and the CEA level was decreased in 12. After chemotherapy was initiated a rise in CEA level occurred on the average 6.5 months later, while the mean time to clinical relapse was 8 months. 5 patients (15%) had stable disease; the CEA level was decreased in 2. In 8 patients (24%) with progressive disease, the mean time for a rising CEA level was 3 months. In our view, a change in the CEA level reflects the effectiveness of combination chemotherapy in patients with advanced gastrointestinal cancer.Keywords
This publication has 3 references indexed in Scilit:
- Treatment of advanced gastrointestinal cancer with 5-fluorouracil and mitomycin CCancer, 1979
- The USE of CEA as an early indicator for gastrointestinal tumor recurrence and second-look proceduresCancer, 1977
- Assessment of serial carcinoembryonic antigen (CEA) assays in postoperative detection of recurrent colorectal cancerCancer, 1976