NATURE OF THE ACTION OF INSULIN ON THE LEVEL OF SERUM INORGANIC PHOSPHATE

Abstract

The blood in-organic phosphate of normal and untreated depancreatized dogs falls after the intraven. admn. of fructose. The rate of entry of fructose from the blood into the tissues of untreated depancreatized dogs does not differ from that in normals. However, the rate of disappearance of injd. glucose from the blood is slower in the absence of insulin. Moderate amts. of glucose do not lead to a significant fall in blood inorganic phosphate. At very high blood glucose levels the rate of tissue entry of the hexose is increased and leads to a significant fall in blood inorganic phosphate. The fall in blood inorganic phosphate is a consequence of rapid entry of hexoses into tissues, and is not a primary, direct action of insulin as previously reported.