RECOVERY CHARACTERISTICS FOLLOWING ANTAGONISM OF ATRACURIUM WITH NEOSTIGMINE OR EDROPHONIUM
Open Access
- 1 May 1984
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 56 (5), 453-457
- https://doi.org/10.1093/bja/56.5.453
Abstract
The evoked reversal characteristics of atracurium were studied in 21 patients using edrophonium or neostigmine and a train-of-four pattern of stimulation. Reversal of residual atracurium-induced neuromuscular blockade was significantly more rapid using edrophonium compared with neostigmine. The ratio of the fourth twitch in the train-of-four to the first twitch—the T4 ratio—was significantly greater when the first twitch (T1) had recovered to 75% of control T1, using edrophonium compared with neostigmine. A T4 ratio of 0.5 was confirmed to be compatible with the reliable and safe reversal of atracurium-induced neuromuscular blockade.This publication has 5 references indexed in Scilit:
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