Antibodies to Denatured Desoxyribonucleic Acid in a Lupus Erythematosus Serum
- 30 September 1961
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 87 (4), 477-484
- https://doi.org/10.4049/jimmunol.87.4.477
Abstract
The reaction between the serum of a patient with disseminated lupus erythematosus and DNA has been studied by quantitative complement fixation. Thermally denatured DNA was shown to be a more reactive antigen than native DNA. Immunologic measurement of melting out and renaturation of the antigen characterized it as DNA. DNase-digested antigen preparations failed to react but were effective inhibitors. Lupus erythematosus (LE) serum detected serologic differences in denatured DNA preparations from various sources.Keywords
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