Effect of Chlorothiazide Therapy on Serum Uric Acid and Uric Acid Excretion

Abstract

DURING preliminary testing in 1957, chlorothiazide revealed its effectiveness as a diuretic for oral administration.¹ It was observed some months later also to have an antihypertensive effect.² The present study was undertaken because of the relation between chlorothiazide and salicylate as inhibitors of uric acid secretion first suggested by Yü and Gutman.³ Material and MethodsTen patients who had been receiving chlorothiazide up to ten months were asked to return to the hospital. During the first forty-eight-hour admission, they had two determinations each of blood urea nitrogen, serum uric acid (by Caraway's⁴ method) and electrolytes, and collected all urine in . . .