THE INFLUENCE OF ZINC STATUS ON THE ANTI-LEWIS LUNG-TUMOR ACTIVITY OF CISPLATIN AND GALLIUM
- 1 January 1981
- journal article
- research article
- Vol. 1 (5), 269-274
Abstract
Treatment of C57/BL mice with cisplatin or gallium nitrate inhibited the growth and metastasis of the [mouse] Lewis lung tumor; these antitumor agents also lowered the Zn levels of some tissues. Nutritional Zn deficiency or the deficiency arising from treatment with the chelating agent, penicillamine, also restricted tumor growth. Although the antitumor activity of cisplatin was enhanced in Zn-deficient mice, many of these animals died before sacrifice 14 days after tumor inoculation. Zn status apparently could have considerable bearing on the therapeutic index of the metal-containing anticancer drugs.This publication has 14 references indexed in Scilit:
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