Synthesis of Methylenecyclobutyl- and Cyclobutenyl Adenine, Potent Antiviral Carbocyclic Analogues of Oxetanocin A
- 1 February 1992
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 11 (2), 855-864
- https://doi.org/10.1080/07328319208021745
Abstract
9-Cyclobutyladenines bearing both methylene and hydroxymethyl groups, 3 and 4, were prepared by dehydration of carbocyclic oxetanocin A (1a). Introduction of a double bond into cyclobutane ring was achieved by allylic oxidation of N 6-benzoyl-9-[3-methylenecyclobutyl]adenine (12), which after several steps, afforded 9-[3-(hydroxy-methyl)-2-cyclobutenyl)adenine (5).Keywords
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