Requirements for adherens junction components in the interaction between epithelial tissues during dorsal closure inDrosophila
Open Access
- 15 September 2007
- journal article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 120 (18), 3289-3298
- https://doi.org/10.1242/jcs.010850
Abstract
Dynamic interactions between epithelial sheets are a regular feature of morphogenetic processes. Dorsal closure in Drosophila relies on the coordinated movements of two epithelia, the epidermis and the amnioserosa, and provides an excellent model system for a genetic and cell biological approach. Here, we have analyzed the contribution of junctional organization of these epithelia to dorsal closure. We observe a stringent requirement for adherens junctions at the leading edge, the interface between the amnioserosa and the epidermis, for the transmission of the forces generated during the process. We also find that interactions between Armadillo and E-cadherin play an important role in maintaining the adhesion at the leading edge, revealing the particular dynamics of this interface. Our results show that regulated cell adhesion is a crucial element of the interactions that shape epithelial sheets in morphogenetic processes.Keywords
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