The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes

Abstract

The Pathogenesis of Thrombus FormationHaving discussed the participation of thrombus formation in the progression of atherosclerosis and in the acute coronary syndromes (Fig. 2 and 5), we shall now examine the local and systemic factors present at the time of coronary plaque disruption that may influence the degree and duration of thrombus deposition and account for the various pathologic and clinical manifestations (Table 2). The Degree of Plaque Disruption As an initial approach to the understanding of the thrombotic process that follows plaque disruption, Badimon et al. have developed a computer-assisted nuclear-scintigraphic method using an extracorporeal-perfusion system to study . . .