Spontaneous double Robertsonian translocations Rb(2.3) and Rb(X.3) in the mouse

Abstract

A double Robertsonian translocation appeared spontaneously in a colony of NMRI mice. The chromosomes involved in both translocations were identified by means of different banding techniques (G, GT, and C bands [Giemsa, Giemsa-trypsin and constitutive heterochromatin, respectively]). The formulation of these associations in the karyotype can be expressed as MMU-38, X, Rob. (2.3) and (X.3). This is the 1st Robertsonian translocation to be reported in the mouse involving the X chromosome. The fundamental number of chromosomes, NF, is 40. The phenotype does not differ from normal. The carrier of the double translocation was a female under study in another experiment; its parents and relatives could not be ascertained.