OXYGEN CONSUMPTION AND PLASMA PROTEINBOUND IODINE FOLLOWING ELEMENTAL IODINE INJECTIONS1

Abstract

Groups of normal, thiouracil-treated and thyroi-dectomized rats were injd. with propylene glycol alone and 4 or 16 mg. elemental I/kg./day dissolved propylene glycol, for 30 days. Study of the metabolic rates during the period of injns. showed no effect in the normals of either levels of I2. A 24% increase in the thiouracil-treated rats resulted from 16 mg. In, but no change from the 4-mg. dosage in this group. The lower amt. of I2 produced a 12%, and the greater a 37% elevation in O2 consumption of the thyroidectomized animals. Considerable elevations in plasma protein-bound I of all animals were produced by both levels of I2, the 4-mg. dose causing rises to 70-120 [mu]g.% and the 16-mg. dose causing rises to 260-340 ug-%-The increases were approx. the same in all 3 types of animals, indicating that the thyroid gland is not involved in the production of the protein-bound iodine.