Enhanced Sensitization in Mice by Simultaneous Injection of Antigen and Specific Rabbit Antiserum.

Abstract

Mice were injected intravenously with a solution of serum albumin (human and bovine) plus specific rabbit antiserum in antigen excess. The antibody response to serum albumin was tested and compared to that obtained in mice injected intravenously with serum albumin alone or with albumin and normal rabbit serum. The results show that antibody response elicited with serum albumin plus specific rabbit antiserum is significantly greater than that elicited using serum albumin alone or with normal rabbit serum.