NEUROMUSCULAR BLOCKADE BY STREPTOMYCIN AND DIHYDROSTREPTOMYCIN
Open Access
- 1 December 1960
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 15 (4), 506-509
- https://doi.org/10.1111/j.1476-5381.1960.tb00271.x
Abstract
Both streptomycin and dihydrostreptomycin in large doses produced neuromuscular blockade in different types of skeletal nerve-muscle preparations. Streptomycin had a quicker, more marked and a longer-lasting action than dihydrostreptomycin. Neostigmine reversed a partial block of streptomycin, but a complete neuromuscular block remained unaffected. Calcium ions antagonized the neuromuscular block of streptomycin rapidly but incompletely.Keywords
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