Effect of Renal and Parathyroid Function on Disappearance of Intravenously Injected Calcium Chloride

Abstract

Nephrectomy reduced the rate of disappearance of intraven. injd. Ca in otherwise normal animals but not in the thyroparathyroidectomized dog. Bilateral ureteral ligation did not alter the rate of disappearance of intraven. injd. Ca. Thyroparathyroidectomy reduced the rate of disappearance of injd. Ca. The increase in serum inorganic P that occurs following intraven. injn. of Ca is inversely related to the rate of disappearance of the injd. Ca. The removal of excess Ca from the circulation is a first order reaction in the nephrectomized, ureteral-ligated and thyro-parathyroidectomized-nephrectomized dogs as well as in the normal animals. This does not hold for the period 5 min. after injn.