Long-term blood pressure changes in renal homotransplantation
- 1 February 1978
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Internal Medicine
- Vol. 138 (2), 233-236
- https://doi.org/10.1001/archinte.138.2.233
Abstract
Long-term blood pressure changes were studied in 50 patients who had undergone renal homotransplantation. Excluded were those subjects with arterial stenosis of the transplanted kidney, acute or rapidly progressive rejection, or recurrent glomerulonephritis, as well as those retaining their own diseased kidney(s). The blood pressure after the end of the first year was stable and, therefore, was utilized as the reference blood pressure for this study. One year after transplantation, hypertension was observed in 20% of the patients. Mean blood pressure was positively correlated with age (P<.01), body weight (P<.001), and serum creatinine level (P<.001), and negatively correlated with maintenance dose of prednisone (P<.01). A higher incidence of hypertension was observed in cadaver kidney transplantation than in living related-donor transplantation. The study minimizes the role of glucocorticoids and emphasizes the role of renal factors in the mechanism of the long-term blood pressure changes. (Arch Intern Med138:233-236, 1978)This publication has 2 references indexed in Scilit:
- Renal HomotransplantationAnnals of Internal Medicine, 1964
- INDUCTION OF ARTERIAL HYPERTENSION IN NORMAL AND ADRENALECTOMIZED RATS GIVEN CORTISONE ACETATEThe Journal of Experimental Medicine, 1952