Paclitaxel Resistance in Non–Small-Cell Lung Cancer Associated With Beta-Tubulin Gene Mutations
- 1 June 1999
- journal article
- lung cancer
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 17 (6), 1786
- https://doi.org/10.1200/jco.1999.17.6.1786
Abstract
PURPOSE: The mechanisms that cause chemoresistance in non–small-cell lung cancer (NSCLC) patients have yet to be clearly elucidated. Paclitaxel is a tubulin-disrupting agent that binds preferential...Keywords
This publication has 29 references indexed in Scilit:
- GML sensitizes cancer cells to Taxol by induction of apoptosisOncogene, 1997
- Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes.Journal of Clinical Investigation, 1997
- Relationship of Mitotic Arrest and Apoptosis to Antitumor Effect of PaclitaxelJNCI Journal of the National Cancer Institute, 1996
- Characterization of a Taxol‐resistant Human Small‐cell Lung Cancer Cell LineJapanese Journal of Cancer Research, 1994
- Phase II Study of Taxol, Merbarone, and Piroxantrone in Stage IV Non-Small-Cell Lung Cancer: The Eastern Cooperative Oncology Group ResultsJNCI Journal of the National Cancer Institute, 1993
- An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) geneCell, 1988
- Tubulin domains probed by limited proteolysis and subunit-specific antibodiesJournal of Molecular Biology, 1985
- Taxol-requiring mutant of Chinese hamster ovary cells with impaired mitotic spindle assembly.The Journal of cell biology, 1983
- CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered β-tubulinCell, 1980
- Promotion of microtubule assembly in vitro by taxolNature, 1979