Paper: Daraprim as an antagonist of folic and folinic acids
- 1 September 1952
- journal article
- research article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 46 (5), 467-473
- https://doi.org/10.1016/0035-9203(52)90038-2
Abstract
Daraprim (5-(p-chlorophenyl)-2,4-diamino-6-ethylpyrimidine) is an antagonist of the folic-folinic acid group of vitamins. Its success as a chemotherapeutic against certain bacteria and several species of plasmodia may be due to this action. The drug seems to act as an antimetabolite and prevents the folic acid contribution to the formation of nucleic acid from developing. Nuclei cannot function properly in metabolic activities, especially those of mitosis, without the proper nucleic acid formation. Daraprim seems to interfere with the multiplication of bacteria and of gametocytes of the plasmodia[long dash]possibly because of this antifolic reaction.Keywords
This publication has 20 references indexed in Scilit:
- 3,5-DIAMINO-AS-TRIAZINES AS INHIBITORS OF LACTIC ACID BACTERIA AND PLASMODIAJournal of the American Chemical Society, 1952
- 2,4-Diaminopyrimidines as Antimalarials. III. 5-Aryl DerivativesJournal of the American Chemical Society, 1951
- 2,4-Diaminopyrimidines as Antimalarials. II. 5-Benzyl DerivativesJournal of the American Chemical Society, 1951
- 2,4-Diaminopyrimidines as Antimalarials. I.1 5-Aryloxyl and 5-Alkoxyl DerivativesJournal of the American Chemical Society, 1951
- STUDIES ON ANALOGS OF PURINES AND PYRIMIDINESAnnals of the New York Academy of Sciences, 1950
- Response of Plasmodium berghei to Anti-malarial DrugsNature, 1949
- 251. Synthetic antimalarials. Part XXI. 4-Arylamino-6-aminoalkylaminopyrimidines. Further variationsJournal of the Chemical Society, 1947
- 74. Synthetic antimalarials. Part VII. 2-Arylamino-4-dialkylaminoalkylaminopyrimidines. Variation of substituents in the 5- and the 6-positionJournal of the Chemical Society, 1946
- 70. Synthetic antimalarials. Part III. Some derivatives of mono- and di-alkylpyrimidinesJournal of the Chemical Society, 1946
- The Effects of Pyrimidines on the Growth of Lactobacillus caseiScience, 1945