HYPERMINERALOCORTICISM WITHOUT EXCESSIVE ALDOSTERONE SECRETION: AN ADRENAL CARCINOMA PRODUCING DEOXYCORTICOSTERONE
- 1 October 1982
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 17 (4), 353-361
- https://doi.org/10.1111/j.1365-2265.1982.tb01600.x
Abstract
A 51-yr-old female was thought to have Conn''s syndrome because she had hypertension, hypokalemia and low plasma renin activity. The cause was not aldosterone excess, but there was an adrenal cortical carcinoma producing 11-deoxycorticosterone (DOC) in extremely large quantities, with ineffective 11.beta.-steroid hydroxylation. Plasma and urinary aldosterone levels were within the normal range. Blood levels of other steroids including those on the pathways of formation of glucocorticoids and sex steroids were unaffected. The tumor was cultured in vitro and shown by high performance liquid chromatography (HPLC) to produce predominantly DOC from tritiated pregnenolone, with no detectable aldosterone, in agreement with the in vivo results.This publication has 18 references indexed in Scilit:
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