A radioimmunoassay method for the rapid detection of Candida antibodies in experimental systemic candidiasis
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Mycopathologia
- Vol. 67 (1), 55-58
- https://doi.org/10.1007/bf00436242
Abstract
Rabbits were employed as experimental models to evaluate a solid-phase radioimmunoassay (RIA) method for the diagnosis of systemic candidiasis. Ten rabbits were inoculated subcutaneously to mimic superficial candidiasis and were found to produce no antibodies to Candida as determined by both immunodiffusion and RIA procedures. However, 94 per cent of 18 rabbits systemically infected by intravenous injection of Candida cells were observed to produce antibody as assessed by the RIA technique. These data encourage further tests with human sera and the continued development of this RIA procedure as a useful tool in the early serodiagnosis of systemic candidiasis.This publication has 20 references indexed in Scilit:
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