Binding of meso-tetra (4-N-methylpyridyl) porphine to DNA
- 1 January 1980
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 8 (12), 2835-2842
- https://doi.org/10.1093/nar/8.12.2835
Abstract
The porphyrin photosensitizer, meso-Tetra (4-N-methyl-pyridyl) porphine tetraperchlorate is shown to unwind supercoiled ColEI DNA at a somewhat lower concentration than ethidium bromide. In contrast to this, the Fe(III) chelate of T4MPyP cannot unwind supercoiled DNA. It is concluded that these results corroborate our previous findings that, despite its large bulk, T4MPyP is fully capable of intercalating in DNA.Keywords
This publication has 12 references indexed in Scilit:
- Binding of cis - and trans -Dichlorodiammineplatinum(II) to DNA: Evidence for Unwinding and Shortening of the Double HelixScience, 1979
- Interaction of DNA with a porphyrin ligand: evidence for intercalationNucleic Acids Research, 1979
- Physiocochemical studies on the interaction of irehdiamine A with bihelical DNABiochemistry, 1977
- A simple electrophoretic method for the determination of superhelix density of closed circular DNAs and for observation of their superhelix density heterogeneityAnalytical Biochemistry, 1976
- Dye titrations of covalently closed supercoiled DNA analyzed by agarose gel electrophoresisBiochemical and Biophysical Research Communications, 1976
- Formaldehyde as a probe of DNA structure. I. Reaction with exocyclic amino groups of DNA basesBiochemistry, 1975
- Stereochemical aspects of the interaction between steroidal diamines and DNANucleic Acids Research, 1975
- Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: Evidence for molecular models involving intercalationJournal of Molecular Biology, 1970
- SUPERCOILED CIRCULAR DNA-PROTEIN COMPLEX IN Escherichia coli : PURIFICATION AND INDUCED CONVERSION TO AN OPEN CIRCULAR DNA FORMProceedings of the National Academy of Sciences, 1969
- Relaxation studies of the proflavine-DNA complex: The kinetics of an intercalation reactionJournal of Molecular Biology, 1969