DEMONSTRATION OF NONSPECIFIC SUPPRESSOR CELLS IN PERIPHERAL LYMPHOCYTES OF CANCER-PATIENTS
- 1 January 1978
- journal article
- research article
- Vol. 38 (2), 288-296
Abstract
The response to phytohemagglutinin of peripheral blood lymphocytes was studied in 169 cancer patients. There was a significant decrease compared with control groups (normal persons and those with benign disease). By selecting cancer leukocyte samples with reactivity to phytohemagglutinin that was increased by carrageenan, a macrophage-toxic agent, and by mixing them with normal lymphocytes, it was demonstrated that the depressed phytohemagglutinin of 6 cancer patients'' lymphocytes was due to the presence of suppressor cells that possibly were monocytes.This publication has 3 references indexed in Scilit:
- Depressed in vitro peripheral blood lymphocyte response to mitogens in cancer patients: The role of suppressor cellsInternational Journal of Cancer, 1977
- Evidence for Splenic Suppressor Cells in C3H/He, T-Cell-Deprived C3H/He, and Nude Mice Bearing a 3-Methylcholanthrene-Induced-Fibrosarcoma 2JNCI Journal of the National Cancer Institute, 1976
- Suppressor Cells in the Spleens of Tumor-Bearing Mice: Enrichment by Centrifugation on Hypaque-Ficoll and Characterization of the Suppressor PopulationThe Journal of Immunology, 1976