Complications from Psychotherapeutic Drugs

Abstract

Antidepressant DrugsTwo new classes of antidepressants were introduced during the past three years: hydrazide and dibenzazepine derivatives. The former are related to isonicotinic acid hydrazide (INH), a potent antimycobacterial agent. Several hydrazides have been marketed: iproniazid, isocarboxazid, phenelzine, phenipramine and nialamide. Although they are used for treating mental depression, their efficacy is not firmly established. Other experimental uses of hydrazide derivatives include treatment of hypertension, angina pectoris and rheumatoid arthritis. Imipramine is the only dibenzazepine derivative yet to appear. The dibenzazepine nucleus is formed by substitution of an ethyl group for the sulfur atom in the phenothiazine nucleus; the . . .