Efficacy of Perimed® antibacterial system on established gingivitis (I). Clinical results
- 1 November 1989
- journal article
- research article
- Published by Wiley in Journal of Clinical Periodontology
- Vol. 16 (10), 630-635
- https://doi.org/10.1111/j.1600-051x.1989.tb01031.x
Abstract
A 6‐month, double‐blind controlled study was conducted on 101 subjects to determine the effect of Perimed1R antibacterial system, containing povidone‐iodine (PVP‐I) and hydrogen peroxide (H2O2). on established gingivitis. Subjects were randomly assigned to one of 4 treatment groups: PVP‐I/H2O2, PVP‐I/H2 O2 H2O2/H2O or H2O. Gingivitis was assessed by the papillary bleeding score (PBS) and plaque by a modified Quigley‐Hein plaque index (PI) at baseline, 3, 12 and 24 weeks. The average baseline PBS and PI for the 4 groups ranged from 2.16–2.31 and 2.87–2.90, respectively. After baseline evaluation, subjects received a supra‐gingival scaling and a subgingival irrigation with their respective rinse. Daily rinses were supervised and subgingival irrigation was repeated every 3 weeks. Duncan's multiple range test determined which groups differed from each other. The mean PI at 24 weeks was lower than at baseline in all groups. PVP‐I had the lowest PI at all time points. The mean PBS at 24 weeks was 1,48 for PVP‐I, 1.62 for H2O2, 1.88 for H2O and 1.34 for PVP‐I/H202, a reduction from baseline of 31%, 27%, 18%, and 38% respectively. The difference between the PBS for PVP‐I/H2O2 and H2O control was significant at each evaluation. There was a 70% reduction in sites with PBS > 3 for PVP‐I/H2O2 between baseline and 24 weeks compared to a 34% decrease in the H2O group. It was concluded that the use of PerimedR could be a beneficial adjunctive treatment for the prevention and control of gingivitis when used with routine oral hygiene procedures.Keywords
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