Solubilization of Brain Benzodiazepine Receptors with a Zwitterionic Detergent: Optimal Preservation of Their Functional Interaction with the GABA Receptors
- 1 March 1983
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 41 (3), 752-758
- https://doi.org/10.1111/j.1471-4159.1983.tb04804.x
Abstract
Rat brian benzodiazepine receptors were solubilized by means of the zwitterionic detergent CHAPS [3-[(3-chlorodipropyl)dimethylammonio]-1-propane sulfonate] under conditions in which the GABA stimulation of [3H]flunitrazepam binding to the benzodiazepine receptors is maintained intact. This stimulation is partially or totally abolished when using other conventional detergents.Keywords
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