Effects of Kallikrein on the Male Reproductive System and its Use in the Treatment of Idiopathic Oligozoospermia with Impaired Motility

Abstract

A single-blind study on the effects of kallikrein in idiopathic oligozoospermia was carried out. 8 of the 16 patients admitted to the trial were treated with kallikrein 100 K.U. t.i.d., the remaining patients received vitamin E 100 mg t.i.d. Treatment lasted 120 days in both groups. Kallikrein led to an increase in sperm concentration, total sperm count and sperm penetration capacity. Patients receiving vitamin E failed to show any improvement. It is postulated that the increase in sperm concentration could be explained by the positive action of kallikrein on spermatogenesis, due to a simulatory effect of the drug directly on the Sertoli cell function and on the circulation in the vascular system of the testis.