Experimental Production of Congenital Anomalies

Abstract

THE purpose of this communication is to sketch the status of acquired congenital anomalies of the mouse against a background of experimental embryology; to report progress in the induction of such anomalies by oxygen lack of different degrees maintained for a five-hour period during pregnancy; and to analyze the part played by fetal age (stage of development) as well as anoxic stress.With such excellent monographs as those of Needham,¹ Brachet² and Weiss³ available, no attempt is made to review the massive body of embryologic knowledge; the literature on the biology⁴ and genetics⁵ of the mouse alone is voluminous. To . . .