Autoradiography in Fetal Syrian Golden Hamsters Treated With Tritiated Diethylnitrosamine23
- 31 March 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 66 (4), 773-777
- https://doi.org/10.1093/jnci/66.4.773
Abstract
Tritiated diethylnitrosamine was administered to female Syrian golden hamsters on each of the last 4 days (days 12-15) of pregnancy. The distribution of bound radioactivity was monitored by light microscopic autoradiography of fetal tracheas and livers, the placentas, and the maternal livers. In the trachea, the fetal target organ, bound radioactivity was restricted to the respiratory epithelium, where diethylnitrosamine-induced tracheal tumors arise. Mucous cells and nonciliated stem cells were identified as the principal sites of binding; other cell types within the tracheal epithelium contained only small amounts of bound radioactivity. The level of binding observed in the fetal trachea increased steadily from day 12 to day 15, which correlated well with the level of differentiation of this tissue during this period. This observation also agrees with the previously reported observation that tumor incidence increases from 40 to 95% in Syrian golden hamsters between days 12 and 15.Keywords
This publication has 3 references indexed in Scilit:
- Pathogenesis of Diethylnitrosamine-Induced Tumors in the Trachea of the Syrian Golden HamsterPathology - Research and Practice, 1980
- Binding of Radioactivity After Transplacental Administration of Tritiated N-Nitrosodiethylamine to Syrian Golden Hamsters2JNCI Journal of the National Cancer Institute, 1980
- Diaplacentare Wirkung des Carcinogens Diäthylnitrosamin beim GoldhamsterZeitschrift für Krebsforschung und Klinische Onkologie, 1965