Mechanism by which uptake inhibitors antagonizep-chloroamphetamine-induced depletion of brain serotonin
- 1 March 1980
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 5 (3), 241-245
- https://doi.org/10.1007/bf00964612
Abstract
The mechanism by which uptake inhibitors antagonizep-chloroamphetamine (PCA)-induced depletion of brain serotonin has been suggested to involve: (1) blockade of PCA uptake into the serotonin neuron by means of the membrane carrier, or (2) blockade of the efflux of released serotonin from the neuron, this efflux also requiring the membrane carrier. According to either mechanism, antagonism of serotonin depletion by PCA would provide a valid index of inhibition of the amine uptake system on serotonin neurons in vivo.This publication has 19 references indexed in Scilit:
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